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Actor, writer and director Harold Ramis died Monday in Chicago at the age of 69. The comedy legend is most known for his work in Hollywood classic comedies Ghostbusters and Groundhog Day.

Ramis was suffering from autoimmune inflammatory vasculities, a disease that causes swelling of the blood vessels reports the Chicago Tribune. Ramis’s fight with the rare disease began in May of 2010.

Ramis started his career in Hollywood 40 years ago when he helped write National Lampoon’s Animal House, which at that time broke box-office records for a comedy movie notes the NY Times.

His comedic style didn’t just get people to laugh but made people think reports USA Today.

According to CNN, Dan Aykroyd, who worked with Ramis on Ghostbusters, posted on Facebook, “Deeply saddened to hear of the passing of my brilliant, gifted, funny friend, co-writer/performer and teacher Harold Ramis. May he now get the answers he was always seeking.”

Ramis leaves behind his wife Erica, his daughter Violet, his two sons Julian and Daniel, and two grandchildren.